Faculty

 

Head of Department of Cardiorespiratory Physiology

 

 

Prof SK Chhabra, MD (Pulmonary Medicine), FCCP, FNCCP (I), FCAI (I)

 

 

Brief CV

 

Prof SK Chhabra did his graduation (MBBS) from Maulana Azad Medical College (1977 batch) and obtained MD in Pulmonary Medicine from the Vallabhbhai Patel Chest Institute in 1986. He joined the Department of Cardiorespiratory Physiology in 1987 as lecturer and has been heading the department since 1995.

 

He is incharge of one clinical unit in the Viswanathan Chest Hospital and the Pulmonary Function laboratory of the Institute. 

 

A chest specialist by training, he has developed keen research  interest in lung physiology, critical care medicine, epidemiology and biochemistry and clinical pulmonary medicine. He has been active in several areas of research, both basic and applied, in the discipline of Pulmonary Medicine and allied sciences. His interests include aspects of asthma, Chronic Obstructive Pulmonary disease, interstitial lung diseases, pulmonary function and health effects of air pollution. Among his pioneering works have been studies on epidemiology of asthma and adverse effects of air pollution. He has developed an experimental model of asthma in guinea pigs and explored the phenomenon of oxidative stress in asthma and COPD. He has explored the basic mechanisms underlying the pathogenesis of bronchial hyperreactivity and airway inflammation in asthma. He has developed regression equations for spirometry norms in children and is currently working on development of equations for spirometry, lung volumes and diffusion capacity in adults in four metropolitan cities of India. Among ongoing projects are investigations into the linkage between COPD and cardiovascular disease. 

 

He was awarded the Von Pirquet prize of the Indian College of Asthma, Allergy and Applied Immunology and the NAPCON-Dr Reddy Oration of the National College of Chest Physicians. He was awarded the Fellowship of the American College of Chest Physicians, National College of Chest Physicians and the Indian College of Asthma, Allergy and Applied Immunology and is on selection panel for scientists of Defense Research and Development Organization. He has been an adviser to the Center for Science and Environment and The Energy Research Institute. He has supervised research work of more than 25 MDs (Pulmonary Medicine) and been a co-supervisor for PhD students. He is an examiner for students of DM (Pulmonary Medicine), MD (pulmonary Medicine) and DTCD. 

 

He has delivered more than 100 guest lectures and has more than a hundred publications in prestigious indexed international and national journals. He is the Editor of Indian Journal of Chest Diseases and Allied Sciences and Associate editor of Journal of the Indian Journal of Asthma, Allergy and Applied Immunology.

 

 

Research Areas

 

Bronchial asthma: Epidemiology, Pathophysiology, Therapeutics, Pathogenesis

 

Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, Autonmic neuropathy, Arrhythmias, Vascular disease

 

Idiopathic Pulmonary Fibrosis: Pathophysiology, Natural history

 

Sarcoidosis: Cardiac involvement, Natural history

 

Allergic bronchopulmonary aspergillosis: Pathophysiology, Natural history

 

Pulmonary Function testing: Development of regression equations, Bronchodilator responsiveness, Interpretation of spirometry

 

Air Pollution: Health effects

 

Ongoing and completed Research Projects

 

Completed

 

1. Multicentric clinical trials of Indigenous drugs in bronchial asthma (Indian Council of Medical Research).

 

2. Study of effects of a stressful occupation on respiratory health (Department of Science & Technology).

 

3. Clinical and Physiological implications of failure of calcium homeostatic pumps in asthma and their modulation by inhaled corticosteroids (Council of Scientific and Industrial Research)

 

4. A study of prevalence of bronchial asthma in school children in Delhi (Indian Council of Medical Research)

 

5. An epidemiological investigation into respiratory morbidity due to air pollution in Delhi (World Health Organisation)

 

6. Bronchodilatation in normal elderly subjects following ipra­tropium bromide and salbutamol aerosols and their effect on other lung functions (Indian Council of Medical Research)

 

7. Efficacy and tolerance of R-salbutamol in bronchial asthma. (Cipla India Ltd).


8. Comparison of addition of salmeterol to fluticasone and doubling of fluticasone in bronchial asthma (Cipla Ltd)


9. Study of Renin-Angiotensin-Aldosterone system in COPD (Cipla Ltd)

 

 

10. Comparison of the efficacy of Ciclesonide MDI with budesonide MDI in stable asthmatic patients pretreated with inhaled corticosteroids (Zydus Byk India Ltd)

 

11. Oxidant-antioxidant balance in bronchial asthma: Evaluation of the role of alpha-tocopherol in treatment (Indian Council of Medical Research)

 


12. Effect of High Dietary Sodium Intake and Inhibition of Sodium-Potassium Adenosine Triphosphatase on Induction of Asthma in Guinea Pigs (Department of Science & Technology)

 

13. Potentiation of allergic asthma by air pollution: The Ozone-Allergen interaction and its modulation by dietary antioxidants, alpha-tocopherol and ascorbic acid. (Indian Council of Medical Research)

 

14. Air Pollution and mortality in Delhi, India . In collaboration with the Energy Research Institute (TERI) and AIIMS, NDMC. (Health Effects Institute, USA)

 

15. Assessment of the Effects of High Particulate Pollutants on Pulmonary Health Status in Selected Mega-cities of South Asia. (National Physical Laboratory)

 

16. Pulmonary Function in Normal Children in Delhi Region. (Indian Council of Medical Research)

 

Ongoing projects

 

1. Pulmonary Function in Normal Adults in India: Development of Reference Standards for Spirometry, Static Lung Volumes and Single Breath Diffusion Capacity. (Indian Council of Medical Research)

 

2. Heart Rate Variability in Chronic Obstructive Pulmonary Disease: Association with Systemic Inflammation and Clinical Implications. (Department of Science & Technology)

 

As Co-Investigator

Projects completed

1. Transmembrane signalling in bronchial asthma. (Department of Science & Technology; Principal investigator Prof SK Bansal, Department of Bochemistry)

2. Multicentric studies on the prevalence of bronchial asthma. (Indian Council of Medical Research, with Dr VK Vijayan. Principal investigator Prof SK Jindal, Department of Pulmonary Medicine, PGIMER, Chandigarh )

3. Prevalence of Mycoplasma pneumoniae infection in patients of acute exacerbations of Chronic Obstructive Pulmonary Disease. (Indian Council of Medical Research  Principal investigator Dr Mandira Varma, Department of Microbiology)
 

4. Study of Virological and biochemical regulatory mechanism of influenza virus induced apoptosis in murine model of allergic asthma. (Council of Scientific & Industrial Research, Principal investigator Dr Madhu Khanna, Department of Virology)

5. Genetic Analysis of Influenza Virus in Clinical Specimens by Rapid Molecular Techniques. (Department of Science & Technology;  Principal investigator Dr Madhu Khanna, Department of Virology)

 

List of Publications

1985-1990

1. Chhabra SK. Modulation of airway reactivity in bronchial asthma by theophylline, disodium cromoglycate and lipotropic factor, choline.  MD (Tuberculosis and Respiratory Diseases) Thesis, University of  Delhi , 1985.

 

2. Mehta D, Gupta S, Chhabra SK , Gangal SV, Agrawal KP. Failure of Ca and Na/K pumps in the leukocytes of asthmatic patients. Fed Proc 1986; 45: 314

 

3. Agrawal KP, Mehta D, Gupta S, Chhabra SK. Metabolic basis for  asthma and rhinitis: an integrated approach. Lung 1986; 164: 279‑291

 

4. Chhabra SK. Bronchial hyperreactivity: Measurement and its applications. Indian J Chest Dis 1986; 28: 222‑230

 

5. Menon MPS, Singla R, Chhabra SK, Bhattacharya D. Mounier Kuhn syndrome.  Indian J Chest Dis 1986; 28: 231‑236

 

6. Chhabra SK. Differing bioavailability of two salbutamol metered dose inhalers. J Asthma 1987; 24: 215‑218

 

7. Singla R, Bhattacharya D, Chhabra SK , Menon MPS. Pleural effusion in renal cell       carcinoma. Indian J Chest Dis 1987; 29: 29‑35

 

8. Menon MPS, Chhabra SK , Singla R, Singh T. Castleman's disease of the lung hilum. Indian J Chest Dis 1987; 29: 44‑51

 

9.  Chhabra SK , Wadehra N, Gaur SN, Joshi AP, Agrawal KP. Prophylactic treatment of bronchial asthma with theophylline, disodium cromoglycate and choline. Indian J Chest Dis 1987; 29: 65‑76

 

10. Menon MPS, Singla R, Chhabra SK. A case of agenesis of right lung with other rare congenital anomalies. Indian J Chest Dis 1987; 29: 98‑102

 

11. Wadehra N,  Chhabra SK, Gaur SN, Joshi AP, Agrawal KP. Abnormalities of lipid metabolism in asthma and rhinitis. Indian J Chest Dis 1987; 29: 131‑137

 

12. Jaiswal A,   Chhabra SK , Singla R, Chopra K, Menon MPS. Mediastinal space occupying lesions: a ten year experience. Indian J Chest Dis 1987; 29: 204‑215

 

13. Chhabra SK, Gaur SN. Airway hyperreactivity in tropical pulmonary eosinophilia. Chest 1988; 95: 560‑561

 

14.  Pant K, Chhabra SK, Chawla R, Jaggi  OP. Modulation of type I skin hypersensitivity reactions by bronchodilators. Indian J Chest Dis 1988; 30: 253‑256

 

15. Pant K, Chhabra SK , Jain SK , Malik GB. Pulmonary alveolar  microlithiasis. Indian J Chest Dis 1988; 30: 141‑147

 

16. Chhabra SK, Gaur SN, Khanna A. Clinical significance of non‑specific bronchial hyperresponsiveness in asthma. Chest 1989; 96: 597‑600

 

17. Chhabra SK, Gaur SN. Effect of long‑term treatment with sodium cromoglycate on non‑specific bronchial hyperresponsiveness in asthma. Chest 1989; 95: 1235‑1238

 

18. Pant K, Mathur RK, Chhabra SK, Jain SK. Pulmonary alveolar microlithiasis with pleural calcification and nephroli­thiasis. Chest 1990; 98: 245‑246

 

  1991-95

19. Chhabra SK, Gaur SN. Reproducibility of histamine inhalation bronchoprovocation test. Indian J Chest Dis 1991; 33: 53‑58

 

20. Chhabra SK. Maximal expiratory flow volume manoeuvre: Within‑subject variability in normal subjects. Indian J Allergy Appl Immunol 1992; 6: 31‑34

 

21.  Jhamb S, Jain SK , Chhabra SK , Chauhan UPS, Agarwal MK. Insects as inhalant allergens in India : Studies on allergenic and antigenic properties, their aerosolization and heterogeneous immune response in patients. Indian J Allergy Appl Immunol 1992; 6: 7‑14

 

22. Chhabra SK. Inhaled steroids in asthma ‑ a coming of age. Indian J Allergy Appl Immunol 1993; 7: 1‑2

 

23. Chhabra SK. Comparison of salbutamol dry powder aerosol with pressurised aerosol. Indian J Chest Dis 1993; 35: 163‑166

 

24. Chhabra SK. Comparison of two techniques of inhalation of a salbutamol metered dose inhaler. J Asthma 1994; 31: 123‑125

 

25. Pande JN, Chhabra S.K. Nocturnal asthma ‑ changing concepts Indian J Chest Dis 1994; 36: 1‑2

 

26.  Chhabra SK. A comparison of salbutamol and beclomethasone dipropionate in moderately severe asthma. Indian J Chest Dis 1994; 36: 119‑124

 

27. Chhabra SK. Comparison of a short course of prednisolone with sustained release theophylline in the control of nocturnal asthma. Indian J Chest Dis 1995; 37: 7‑14

 

28.  Chhabra  SK. An epidemiological investigation into nocturnal asthma. J Asthma 1995; 32: 147‑150

 

29. Chhabra SK. Beclomethasone dipropionate is effective in the control of nocturnal asthma. Lung India 1995; 13: 127-131

 

1996-2000

 

30.  Chhabra SK , Pamela Singh, Shashi Jhamb, Agarwal MK. Duration of inhibitory effect of terfenadine on histamine‑induced skin wheals. Ann Allergy Asthma Immunol 1996; 76: 373-375

 

31. Chhabra Pragati, Garg S, Mittal SK, Chhabra SK. Risk factors for acute respiratory infections in underfives. Indian J Maternal Child Hlth 1997; 8: 13 -17

 

32. Chhabra SK. FVC, SVC or IVC - Which is the best measure of vital capacity. J Asthma 1998; 4: 361-366

 

33. Chhabra SK. Late asthmatic response in exercise-induced asthma. Annals of Allergy 1998; 80: 323-327

 

34. Chhabra SK, Gupta CK, Chhabra P, Rajpal S. Prevalence of bronchial asthma in schoolchildren in Delhi J Asthma 1998; 3: 291-296

 

35. Chhabra SK. Epidemiology of childhood asthma. Indian J Chest Dis Allied Sci 1998; 40: 179-195

 

 

36. Chhabra SK. Idiopathic pulmonary fibrosis: Prognostic indicators. Indian J Chest Dis Allied Sci 1998; 40: 159-162

 

37.  Chhabra SK , Khanduja K, Jain D. Decreased sodium-potassium and calcium adenosine triphosphatase activity in asthma: modulation by inhaled and oral corticosteroids. Indian J Chest Dis Allied Sci 1999; 41: 15-26

 

38. Chhabra SK. Antileukotriene drugs: have these truly arrived. Indian J Chest Dis Allied Sci 1999; 41: 1-4

 

39. Chhabra SK, Khanduja K, Jain D. Increased intracellular calcium and decreased activity of leukocyte sodium-potassium and calcium adenosine triphosphatase in asthma. Clinical Science 1999; 97: 595-601

 

40. Chhabra SK. Gupta CK, Chhabra P. Risk factors for development of bronchial asthma in children in Delhi . Ann Allergy Asthma Immunol 1999; 83: 1-6

 

41.  Chhabra SK. The rising menace of environmental tobacco smoke Indian J Chest Dis Allied Sci 1999; 41: 191-194

 

42.  Chhabra SK , Rajpal S, Chhabra P, Gupta R. Ambient air pollution and chronic respiratory morbidity in Delhi . Archives Environ Hlth 2001; 56: 58-64

 

43.  Chhabra  SK , M Gupta. Prednisolone hastens recovery from histamine-induced bronchospasm in asthmatics. J Asthma 2000; 37: 435-440

 

44. Jain D, Raj HG, Chhabra SK (Author for correspondence).  Long term stability of bronchial reactivity in guinea pigs. Indian J Chest Dis & Allied Sci 2000; 42: 3-7

 

2001

 

45. Aggarwal S, Chhabra SK, Saxena RK, Agarwal MK. Heterogeneity of immune response to various aspergillus species in patients with allergic respiratory disorders. Indian J Chest Dis & Allied Sci 2001; 42: 249-258

 

46.  Chhabra SK , Rajpal S, Gupta R. Patterns of smoking in Delhi : Comparison of respiratory morbidity among Bidi and Cigarette smokers. Indian J Chest Dis & Allied Sci 2001; 43: 19-26

 

47. Chhabra SK. FVC response in bronchoreversibility test. Indian J Chest Dis Allied Sci 2001; 43: 9-11

 

48.  Chhabra SK , Vatsa HK. Advantages of late expiratory relaxation during maximal forced expiratory maneuver. Indian J Chest Dis & Allied Sci 2001; 43: 205-210

 

49.  Chhabra SK , Gupta RK. Allergic bronchopulmonary aspergillosis with cavitary lesion simulating a lung abscess. Indian J Chest Dis & Allied Sci 2001; 43: 173-176

 

50.  Chhabra SK , Gupta RK. Cutis laxa and emphysema. Indian J Chest Dis & Allied Sci 2001; 43: 235-238

 

51. Jain Deepika, Raj GH, Gangal SV, Chhabra SK (Author for correspondence). Relationship between intracellular calcium and airway reactivity in guinea pigs. Jpn J Physiol 2001; 51: 577-583

 

52. Khanna M, Kumar P, Chugh L, Prasad AK , Chhabra SK. Evaluation of influenza virus detection by direct immunoassay (EIA)  and conventional methods in asthmatic patients. J Commun Dis 2001; 33: 163-169

 

2002

53. Chhabra SK. Air pollution and Health. Indian J Chest Dis & Allied Sci 2002; 44: 9-11

54.  Chhabra SK , Pandey KK. Comparison of acute bronchodilator effects of inhaled ipratropium bromide and salbutamol in bronchial asthma J Asthma 2002;39:375-81

 

55.  Chhabra  SK , Bhatnagar S. Comparison of Bronchodilator Responsiveness in Asthma and Chronic Obstructive Pulmonary Disease. Indian J Chest Dis & Allied Sci 2002; 44: 91-97

 

56.  Chhabra SK , Vijayan VK, Gupta RK, De Sajal. Expression of bronchodilator response: comparison of four indices. Respir Medicine 2002; 96: 611-614

 

57. Gupta RK, Chhabra SK. An evaluation of salmeterol in the treatment of chronic obstructive pulmonary disease (COPD) Indian J Chest Dis & Allied Sci 2002;44:165-72

 

2003

58. Nadeem A., ChhabraSK, Masood A, Raj HG. Increased oxidative stress and altered levels of antioxidants in asthma. J Allergy Clin Immunol 2003; 111: 72-8

 

59. Chhabra SK. Measuring health-related quality of life in asthma. Indian J Chest Dis & Allied Sci 2003; 45: 9-12


60. Dhiwakar M, Thakar A, Bahadur S, Sarkar C, Banerji U, Handa KK, Chhabra SK. Laryngoscope 2003; 113 :688-94

2004

61.  Chhabra SK , De Sajal. Clinical significance of hilar thoracic index and width of right descending branch of pulmonary artery in chronic obstructive pulmonary disease Indian J Chest Dis & Allied Sci 2004; 46: 91-97

62. Chhabra SK. Assessment of response to treatment in COPD. Chest ( India ) 2004; 5: 309-311

 

63. Jain Deepika, Raj GH, Gangal SV, Chhabra SK (Author for correspondence). Effect of sensitization on membrane ion fluxes and intracellular calcium in guinea pigs Indian J Med Res 2004; 120: 534-541

 

64.  Chhabra SK. Does increased dietary salt intake worsen asthma? Indian J Chest Dis & Allied Sci 2004; 4: 247-250

 

2005 

65.  Chhabra SK , De Sajal. Cardiovascular autonomic neuropathy in Chronic Obstructive Pulmonary Disease. Respir Med 2005; 99: 126-133

66. Charanjeet Kaur, Bansal SK, Chhabra SK. Study on serum and urinary cortisol levels of asthmatic patients after treatment with high dose inhaled beclomethasone dipropionate or budesonide. Indian J Chest Dis & Allied Sci 2005; 47: 89-95

 

67.  Chhabra SK , Kaushik S. Validation of the Asthma quality of life questionnaire (AQLQ-UK English version) in Indian asthmatic subjects. Indian J Chest Dis & Allied Sci 2005; 47: 167-174

 

68. Chhabra SK. Premenstrual asthma. Indian J Chest Dis & Allied Sci 2005; 47: 109-116

69. Chhabra SK. Guidelines for management of asthma: The gaps between theory and practice. Indian J Chest Dis & Allied Sci 2005; 47: 77-80

 

70. Chhabra SK. Acute bronchodilator response has limited value in differentiating bronchial asthma from COPD. J Asthma  2005;42:367-72

 

71. Jain Deepika, Raj HG, Chhabra SK. Effects of Vitamin E on Airway Responses and Biochemical Parameters in Guinea Pigs Sensitized to Ovalbumin. Resp Physiol Neurobiol. 2005; 146:231-8

 

72.  Chhabra SK , Gupta U. Diagnosing tubercular pleural effusions. Chest 2005 ;127:1078

 

73. Nadeem A., Chhabra SK , Masood A, Raj HG. Increased oxidative stress in acute exacerbations of asthma. J Asthma 2005;42:45-50

 

74. Nadeem A., Chhabra SK, Raj HG. Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease. Inflammation. 2005; 29:23-32

75. Agrawal A, Agrawal KP, Ram A, Sondhi A Chhabra SK, Gangal SV, Mehta D.Basis of rise in intracellular sodium in airway hyperresponsiveness and asthma. Lung. 2005; 183:375-87

 

2006

76. Chhabra SK. Epidemiology of childhood asthma. Indian J Paediatr 2006; 73: S1-S4

77. Chhabra SK, Ailawadhi M. Effect of prednisolone on lung function and bronchodilator responses in stable COPD. Lung India 2006; 23: 8-14

78. Chhabra SK, Vijayan VK, Vasu T. Inhaled Formoterol versus Ipratropium Bromide in Chronic Obstructive Pulmonary Disease. Indian J Chest Dis & Allied Sci 2006; 48: 97-102

79. Jindal SK, Aggarwal AN, Chaudhary K, Chhabra SK, D'Souza GA, Gupta D, Katiyar SK, Kumar R, Shah B, Vijayan VK; Asthma Epidemiology Study Group. Tobacco smoking in India: prevalence, quit-rates and respiratory morbidity. Indian J Chest Dis Allied Sci. 2006; 48:37-42

80. Gupta D, Aggarwal AN, Chaudhary K, Chhabra SK, D'Souza GA, Jindal SK, Katiyar SK, Kumar R, Shah B, Vijyan VK; Asthma Epidemiology Study Group. Household environmental tobacco smoke exposure, respiratory symptoms and asthma in non-smoker adults: a multicentric population study from India. Indian J Chest Dis Allied Sci. 2006; 48:31-6

 

81. Jindal SK, Aggarwal AN, Chaudhary K, Chhabra SK, D'Souza GA, Gupta D, Katiyar SK, Kumar R, Shah B, Vijayan VK; Asthma Epidemiology Study Group. A multicentric study on epidemiology of chronic obstructive pulmonary disease and its relationship with tobacco smoking and environmental tobacco smoke exposure. Indian J Chest Dis Allied Sci. 2006; 48:23-9

 

82. Aggarwal AN, Chaudhary K, Chhabra SK, D'Souza GA, Gupta D, Jindal SK, Katiyar SK, Kumar R, Shah B, Vijayan VK; Asthma Epidemiology Study Group. Prevalence and risk factors for bronchial asthma in Indian adults: a multicentre study. Indian J Chest Dis Allied Sci. 2006;48:13-22

 

83. Chhabra SK. Chronic obstructive pulmonary disease and cardiovascular disease. Indian J Chest Dis Allied Sci. 2006;48:95-96

 

84. Chhabra SK. Bronchial asthma. Phy Digest 2006; 15: 7-24

 

85. Chhabra SK. Asthma and chronic obstructive pulmonary disease: are they the same or are they distinct diseases? Am J Respir Crit Care Med. 2006; 174:1056

86.  Chhabra SK , Chhabra P. Evolution from typical to atypical radiological appearances – a case report. Indian J Radiol Imaging 2006; 16: 869-873

 

2007