Madhu Khanna 

 

Summary

As the head of the virology department for the past 19 years, my research has been primarily focused on viral pathogenesis, the development of novel antiviral strategies, and vaccine delivery approaches against emerging and re-emerging viral infections, which include influenza, dengue, chikungunya, and SARS-CoV-2. One of my primary responsibilities is to provide accurate diagnoses of respiratory viruses in clinical specimens from both outpatients and inpatients at our institute. Our laboratory has been designated by the ICMR as a centre for COVID-19 and influenza virus diagnosis. Our recent achievements include the development of a peptide immunogen against the dengue virus and also designed an engineered virus against the influenza virus using antiviral elements such as si-RNA, ribozyme, and antiviral peptides to inhibit the viral replication. My PhD students are also working on liposome-based RNA vaccine delivery and targeted engineered exosomes mediated delivery in dendritic cells as vaccine candidate against influenza virus. Our laboratory has successfully generated recombinant antibodies against the HA gene of the influenza virus. These antibodies have shown effectiveness in neutralizing the H1N1 strain of influenza virus, thereby demonstrating their potential for therapeutic and diagnostic applications. Our group has also explored plant-based antiviral remedies. For instance, we have evaluated the antiviral activity of plant extracts like Ajwain and Suramin against influenza A virus replication. Additionally, we have tested Quercetin, a plant polyphenol, which decreased virus-induced oxidative stress and protected lungs against oxygen-derived free radicals.

Our team ultimate aim is to improve prevention strategies, diagnostic techniques, treatment methods, and control measures for viral diseases that pose significant threats to human health and well-being.

 

Madhu Khanna

CURRICULUM VITAE

Address

Home C34, Pusa campus Pin.110012 India Telephone: +91-124-4074922 Mobile: +91-9958524922 Email: madhukhanna@hotmail.com

Work

Professor
Department of Microbiology (Virology)

VP Chest Institute

University of Delhi, Delhi 110007

India
Telephone: +91-11-27667441 (132) (W)

 

Personal Details

Marital status: Married
Nationality: Indian

 

Education

Ph.D. (Lucknow University) from KG. Medical College, Department of Virology Thesis supervisor Professor UC Chaturvedi, Head, Department of Microbiology, KG Medical College, Lucknow, India.           

 

Thesis title Purification and characterization of dengue virus induced cytotoxic factor.

 

 Teaching Experience

Name of the Institution	Designation with pay scale	Nature of post	Classes taught/type of duties	Period From To	Total Experience
Vallabhbhai Patel Chest Institute	Professor	Permanent Research / Teaching	MD and PhD   Microbiology	31.12.2008   till date	Total experience 23 years 3 months
					14 years 6 months (Present post)
Vallabhbhai Patel Chest Institute	Associate Professor	Permanent Research / Teaching	MD Microbiology & M.Sc. Virology (At ACBR)	20.10.2004          to    30.12.2008	4 years 2 months
AIIMS Department of BiochemistryNew Delhi.	Research Officer	Temporary Research & Teaching	Undergraduates (B.Sc)	1st May 1996 to                     23 June 1997	1 year & 1 month
AIIMS Department of Biochemistry	Research Associate	Temporary Research & Teaching	Undergraduates (B.Sc.)	1st Sept 1992 to 30 April 1996	3 years  & 7 months

 

 

 

Research Interests

·      Molecular diagnosis of viruses

·      Pathogenesis of virus

·      Antiviral strategies

 

PhD/MD students guided

Ø  10 PhD & 4 MD (Dissertation) theses awarded

Ø  2 pursuing PhD

 

International Research Trainings

Ø  European Society of Clinical Microbiology and Infectious Disease (ESCMID) fellowship for Observer ship, 23th to 30th November 2017 held at Dept. of virology, University Medical Center Groningen (UMCG), Groningen, Netherlands.

Ø  The Baltic Summer School, International Training Course on "Current Trends In Immunology And Signal Transduction" Including Practical Course On Immunology and Molecular Biology Techniques at University of Kiel, Germany from Sept.17-Oct.8, 2001.

Ø    BOYSCAST Fellowship from Department of Science and Technology, GOI in the 2000, to work at WHO  Collaborating Center for reference and research on Influenza, Australia, Melbourne and Royal Children’s Hospital, Melbourne.

Ø  International Training Course on Cellular and Molecular Biology sponsored by WHO & ICRO held at Weizmann Institute, Israel on 10 Dec.1994 to 23 Dec.1994

National Trainings

Ø  Conference-cum-Training Programme on Current Trends in Nitric Oxide Research: A Translational Approach at V.P Chest Institute held on 5^th April 2023.

Ø  Workshop-cum-Training Programme on ‘Proposal Writing and ethical issues in Biomedical Research , under aegis of Multi-disciplinary Research Unit(MRU), VPCI, Delhi held on 11^th March 2021

Ø  Workshop on Research Methodology and Scientific Paper Writing Techniques for Multi- Disciplinary Research Units and Model Rural Health Research Units at Dr. Rajendra Prasad Govt. Medical College, Tanda,  Dharamshala, Himachal Pradesh held from 5^th September to 6^th September 2019

Ø  CPCSEA Nominee Training Program at National Institute of Animal Welfare, Faridabad held from 14^th January 2013 to 18^th January 2013.

Ø  Workshop on Laboratory Biosafety and Biosecurity at High Security Animal Disease Laboratory, IVRI, Anand Nagar, Bhopal held from 17^th August 2011 to 19^th August 2011.

Ø  Regional Workshop on Avian Influenza Preparedness and Response at Taj Palace Hotel, New Delhi held from 5^th March 2007 to 9^th March 2007 organized by NICD, Delhi.

Ø  CME Programme in Lady Hardinge Medical College and Associated hospitals, New Delhi held on 10^th August 2002.

Professional Affiliations

Ø  Ex Secretary General, Biotechnology Society of India

Ø  Joint Secretary, International Association of Medical and Pharmaceutical         Virologists (IAMPV)

Ø  Ex member of Executive Council of Indian Immunology Society of India (IIS), 2017

Ø  Life member: Indian Immunology Society since 1995

Ø  Life member: Biotechnology Society of India since 2004

Ø  Life member: Influenza Foundation of India from 2010

Ø  Life member: Indian Virological Society from 2010

International Member

Ø  International Society for Influenza and other Respiratory Viruses    Member European Society of Microbiology and Infectious Disease (ESCMID) from 2014

Ø  European Society for Clinical Virology (ESCV)

Ø  Asia-Pacific Alliance for the Control of Influenza (APACI)

Ø  International Society for Influenza and other Respiratory Virus Disease (ISIRV)

Nominee for Animal Ethical Committee

Ø  Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) main nominee, IMT Ghaziabad From August 2023

Ø  CPCSEA – IAEC Member for Shri Ram Institute Delhi till 2023 January

Ø  CPCSEA -IAEC Link Nominee for Indira Gandhi from 25^th July, 2014 to 24^th July 2017. National Open University Maiden Garhi, New Delhi

Ø  CPCSEA- IAEC Member Link Nominee for Amity University Campus Noida

Ø  CPCSEA -IAEC Member Link Nominee for Jamia Hamdard University New Delhi.

Ø  CPCSEA –IAEC Member for Vardhman Mahavir Medical Collage and Safdarjung Hospital, New Delhi from 12.8.2014 to 11.8.2017

Ø  Member Governing body of VP Chest Institute (  in the year 2014 -2015 &  2017&2018

Conferences Organized

Ø  Short term course on Basic and Molecular virology held on 5^th June – 5^th July 2023.

Ø  Pre-conference workshop on “Molecular  diagnostic methods in respiratory infections” (Part of MICROCON-2012), held at VPCI, Delhi (21 November, 2012)

Ø  Annual conference of Biotechnology Society of India entitled “BIOTECH-2012”, at                ILBS, New Delhi

Organizing Secretary of following conferences:

Ø  National Workshop on “Advancement in Immunology”(12^thOctober - 13^thOctober 2017)

Ø  Asia-Pacific Alliance for the Control of Influenza (APACI) International Workshop on “Epidemiology & Control of Influenza-2014” (7th -8th November 2014)

Ø  Organized a ‘National workshop’ on “Hands-on Training in Molecular Techniques in Biotechnology” for Biotechnology Society of India, at Vallabhbhai Patel Chest Institute, University of Delhi, Delhi-11007 on 23rd -24th December 2013.

Ø  Organized a guest lecture of Prof. Mridula Bose for Biotechnology Society of India at Vallabhbhai Patel Chest Institute, University of Delhi in 2013.

Ø  Organized a ‘National workshop’ on “Hands on Training on Molecular Techniques for Detection of Viral Infections” at Dept. of Respiratory Virology, V. P. Chest Institute, University of Delhi, 3rd March 2011.

Ø  Organized a conference entitled “New Frontiers in Drug Discovery and Development Against Emerging & Re-emerging Viral Infections” at Paintal Memorial Golden Jubilee Auditorium, V. P. Chest Institute, University of Delhi, 3rd -5th March 2011.

Ø  Organized a guest lecture of Dr. HK Pradhan, Former Director, National Institute of High Security Animal Diseases, Bhopal and WHO consultant, for Biotechnology Society of India at Vallabhbhai Patel Chest Institute, University of Delhi in 2011.

Ø  National Symposium on Influenza: Epidemiology and Control, at V. P. Chest Institute, University of Delhi, April 5th 2005.

Awards and Honors

1. Bronze award (AVG Award) for the best paper in Ditan International Conference                              on Infectious Diseases, Beijing, China on July, 30-Aug 2, 2009.                                                      

2.      Young Scientist award, European Scientific Working Committee (ESWI), 14-17 Sept, 2008, Portugal.

3.      Young investigator award in “Options for the Control of Influenza VI” Ontario, Canada 17-23 June, 2007(Oral presentation).

 

4.     BOYSCAST Fellowship from Department of Science and Technology, GOI in the 2000, to work at WHO Center for reference and research center Australia, Melbourne.

 

5.     Shakuntala Amir Chand Award of Indian Council of Medical Research (ICMR) for the year 1992 for outstanding research work in the field of "Cytokine Mediated Pathology of Dengue-virus Infection".

 

6.     DST Young Scientist independent scheme on Characterization of drug resistant clinical isolates of M. tuberculosis by PCR analysis. Cost Rs. 5,00 000

 

7.   CSIR Individual fellowship of Research Associate for the project entitled: Spontaneous Release of Interleukin-2 and Generation of Superoxide In Active Pulmonary Tuberculosis

 

8.   BEST POSTER AWARD during the XXII Annual Conference of Indian Immunology Society & National Symposium on Immunology of Infectious Disease, held during 15-17 Dec. 95, JNU, New Delhi, India.

 

9.      Bill & Melinda Gates Foundation’s ‘Global Health Award’ to attend Keystone symposia on “Advancing vaccine in the genomic era” held from Oct. 31- Nov. 4, 2013 at Brazil.

 

Reviewer of following Journals

·         PLOS One

·         Indian Journal of Medical Microbioloy

·         IJMR

·         IJCD

·         Virology Journal

·         Infection Genetics &Evolution

·         Epidemiology  & Infection

·         Frontiers in Pharmacology

 

Editor of international journals

·         Frontiers in virology

·         International Journal of Immunology Research

·        Journal of Virology Research

Editor of National journal

• Indian Journal of Chest Diseases and Allied Sciences

 

 

International Project

1.       Profile of antibody responses and duration of protection following influenza vaccination for adults >65 years old	APACI	2013	USD 30,604	Completed
2.       Multi-Site Monitoring of Human Influenza Viruses in India Phase-I”(PI)	Centre for disease control Atlanta & ICMR, GOI	Sep. 2006-28 Feb. 2010	1 Crore	Completed

 

National Projects (Sponsored by GOI)

 

	Name of the Project	Funding  Agency	Date of Sanction	Total Approved Cost of the Project (in Rs.)	Status
	Exosomes mediated targeted delivery of influenza virus	DST-SERB	2023	50 Lakhs	Ongoing
	Triple targeting engineered            virus: A tool to counter influenza infection	ICMR	2020	37 Lakhs	Ongoing
	3.      Aptamer RNA-Chimera –    the next generation RNA vaccine	DST-SERB	October 2016	40 Lakhs	Completed
	4.      Evaluation of antiviral activity of medicinal plants against influenza A virus	AYUSH	Jan 2014	25 Lakhs	Completed
	5.      To study the heterosubtypic immunity provided by pandemic influenza A H1N1 (2009) virus infected cells.	CSIR	Oct 2013	30 Lakhs	Completed
	6.      Recombinant monoclonal antibodies against influenza A virus and pandemic     influenza 2009 (PI)	DST	Jan. 2011	43.5 Lakhs	Completed
	7.      Study of antigenic diversity and cross reactive antibody generation to influenza virus in human samples (PI)	DRDO	Apr. 2011	45.2 Lakhs	Completed
	A combinatorial antiviral approach against influenza A virus using ribozymes and siRNAs ( PI)	DBT	Nov. 2006	40.2 Lakhs	Completed
	A Study of Viral Replication Inhibition by Down Regulation of NS1 Gene of    Influenza A Virus (PI)	CSIR	Oct 2007-Oct 2010	13 Lakhs	Completed
Typing and subtyping of influenza virus by RT-PCR (PI)		DST	Dec.1998	37.5 Lakhs	Completed
11.  Study of Virological and biochemical regulatory mechanism of influenza virus induced apoptosis in murine model of allergic asthma (PI)		CSIR	Feb 2003	13 Lakhs	Completed
12.  Genetic analysis of influenza virus by molecular techniques (PI)		DST	Nov 2003	18 Lakhs	Completed

 

International Conferences Attended

S. No	Name of conference/ workshop	Year	Place
1	Berlin Influenza Conference BIC 2005	26th May-28th May 2005	Berlin , Germany
2	3rd Orthomyxovirus Research Conference	28th -31th July 2005	Cambridge U.K.
3	Option for the control of influenza	17-23June 2007	Toronto, Canada
4	Third European influenza conference of influenza	September 14-17, 2008	Portugal
5	33rd Ditan international conference on infectious diseases (DICID)	30July -2 Aug 2009	Beijing , China
6	International conference on emerging infectious Disease	11-14 July 2010	Atlanta, Georgia, USA
7	Options for the control of influenza	2nd-7th  September 2010	Hong Kong , China
8	4th European Working Society for influenza virus (ESWI) conference	11th September -14th September 2011	Malta
9	International congress on infectious disease (ICID)	13-16 June 2012	Bangkok
10	3rd ICGEB international  workshop on Human RNA viruses	3-5 April 2012	Buenos Aries, Argentina
11	Options for The Control of Influenza	5-10 September 2013	Cape Town, South Africa
12	Keystone Symposia on  Advancing vaccines in the genomics era	30th October to 5th November 2013	Brazil
13	International conference on antiviral research	12th to 16th 2014	Raleigh , USA
14	Global submit on virology	27th to 29th April 2015	Dubai
15	The 4th ISIRV Antiviral Group conference	2nd to 4th  June 2015	Texas, USA
16	APACI influenza workshop	24th October 2016	Kuala Lumpur. Malaysia
17	Keystone symposia on Hemorrhagic fever viruses	4th to 8th December 2016	New Mexico. USA
18	Prevention and treatment of RVIs: Antivirals, traditional therapies and host-direct intervention	14th to 16th June 2017	Shanghai , China
19	International conference on 3rd Global Virology congress & Expo	6th August 2018	Valencia, Spain
20	Immunological assay and correlation of protection for next generation influenza vaccines	31st March -2nd April 2019	Siena , Italy

 

 

 

 

List of Publications

 

Total impact factor = 293.709

Total H-Index = 5300

1.       Agrawal N, Khanna M, Dhawan G (2023). Identification of suitable house-keeping genes during chikungunya virus infection. Indian Journal of Medical Microbiology 42, 49-52 (IF-1.347, HI-53). https://doi.org/10.1016/j.ijmmb .2023.01.007

2.       Khanna M, Varma Basil M, Manocha N, Agarwal N,  Chauhan V,  Arora R,  Guleria A,  Kumar C,  Choudhary J,  Singh A,  Shrivastava K,  Kumar H,  Goel N,  Spalgais S, Mrigpuri P,  Kumar R (2022). Viral Load-based Evaluation of the Sensitivity of Antigen-based Rapid Detection Assay for SARS-CoV-2. Indian Journal of Chest Diseases and Allied Sciences, Volume 64 Issue 3 (IF-0.043, HI-29). http://dx.doi.org/10.5005/jp-journals-11007-0042

3.       Agrawal, N., Saini, S., Khanna M., Dhawan, G., & Dhawan, U. (2022). Pharmacological Manipulation of UPR: Potential Antiviral Strategy Against Chikungunya Virus. Indian Journal of Microbiology, 62(4), 634–640 (IF-3.54, HI-58). https://doi.org/10.1007/s12088-022-01046-5

4.       Goel N, Goyal N, Spalgais S, Mrigpuri P, Shankar Nagaraja R, Varma-Basil M, Khanna M, Menon B, Kumar R (2022). Initial COVID-19 severity and Long-COVID manifestations: An observational analysis. Thoracic Research Practice; 24(1): 22-28 (IF-0.9). https://doi.org/10.5152/thoracrespract.2023.21307    

5.        Nandi T, Khanna M, Anti-viral activity of suramin against influenza A virus in A549 cells. Indian Journal of Microbiology Research 2022;9(3):190-194 (IF- 1.49). https://doi.org/10.18231/j.ijmr.2022.034

6.       Nandi T and Khanna M, Anti Viral Activity of Thymol Against Influenza A Virus. EC Microbiology  18.8 (2022): 98-103

7.       Khanna, M., Agrawal, N., Chandra, R., & Dhawan, G. (2021). Targeting unfolded protein response: a new horizon for disease control. Expert Reviews in Molecular Medicine, 23, e1 (IF- 7.615, HI- 88).  https://doi.org/10.1017/erm. 2021.2

8.       Rajput, R., Sharma, J., Nair, M. T., Khanna, M., Arora, P., & Sood, V. (2020). Regulation of Host Innate Immunity by Non-Coding RNAs During Dengue Virus Infection. Frontiers in Cellular and Infection Microbiology, 10, 588168 (IF- 6.73, HI-105).  https://doi.org/10.3389/fcimb.2020.588168

9.       Goel, N., Spalgais, S., Mrigpuri, P., Khanna, M., Menon, B., & Kumar, R. (2020). Characteristics of COVID-19 at a non-COVID tertiary pulmonary care centre in Delhi, India. Monaldi Archives for Chest Disease = Archivio Monaldi per le malattie deltorace, 90(4),10.4081/monaldi.2020.1568(IF-1.9,HI-49).   https://doi.org/10.4081/monaldi.2020.1568

10.   Asha, K., Khanna, M., & Kumar, B. (2021). Current Insights into the Host Immune Response to Respiratory Viral Infections. Advances in Experimental Medicine and Biology, 1313, 59–83 (IF-3.65, HI-142).   https://doi.org/10.1007/ 978-3-030-67452-6_4

11.   Kumar, M., Hooda, P., Khanna, M., Patel, U., & Sehgal, D. (2020). Development of BacMam Induced Hepatitis E Virus Replication Model in Hepatoma Cells to Study the Polyprotein Processing. Frontiers in Microbiology, 11, 1347 (IF-5.2, HI-201). https://doi.org/10.3389/fmicb. 2020.01347

12.   Khanna, M., Gautam, A., Rajput, R., & Sharma, L. (2020). Natural Products as a Paradigm for the Treatment of Coxsackievirus - induced Myocarditis. Current Topics in Medicinal Chemistry, 20(8), 607–616 (IF-3.57,HI-127).  https://doi.org/10.2174/1568026620666200129094516

13.   Khanna, M., Manocha, N., Himanshi, Joshi, G., Saxena, L., & Saini, S. (2019). Role of retroviral vector-based interventions in combating virus infections. Future Virology, 14(7), 473–485 (IF-3.015, HI-43).  https://doi.org/10.2217/fvl-2018-0151

14.   Pati DR, Sharma S, Kumar B, Singh V, Khanna M(2019) Evaluation of respiratory virus pathogen from patients presenting with influenza like illness at various hospitals in Delhi, India. Journal of Pulmonary Medicine & Respiratory Research 5: 023 (IF-0.57). http://dx.doi.org/10.24966/PMRR-0177/100023

15.   Khanna, M., Saini, S., Shariff, M., Ronsard, L., Singh, J. K., & Kumar, H. (2019). Data highlighting miR-155 and GAPDH correlation. Data in Brief, 24, 103945 (IF-1.2, HI-45)  https://doi.org/10.1016/j.dib.2019.103945

16.   Asha, K., Kumar, P., Sanicas, M., Meseko, C. A., Khanna, M., & Kumar, B. (2018). Advancements in Nucleic Acid Based Therapeutics against Respiratory Viral Infections. Journal of Clinical Medicine, 8(1), 6 (IF-4.964, HI-95).            https://doi.org/10.3390/jcm8010006

17.   Kumar, B., Asha, K., Khanna, M., Ronsard, L., Meseko, C. A., & Sanicas, M. (2018). The emerging influenza virus threat: status and new prospects for its therapy and control. Archives of Virology, 163(4), 831–844 (IF-2.685, HI-117).  https://doi.org/10.1007/s00705-018-3708-y

18.   Khanna M, Nandi T, Roy S and Saini S. (2016). Zika Virus: A Brief Overview. Austin Virol and Retrovirology. Vol.18:295-301 (IF-3.3).

19.   Khanna M, Agrawal N, Gupta S, Saini S, Kumar B, Kumar J, Kumar H, Malini S and Saini S. (2016). Prevalence of Respiratory Viruses in Exacerbation of Chronic Obstructive Pulmonary Disease. Austin Virol and Retrovirology. 3(1): 1018 (IF-3.3).

20.   Khanna, M., Saxena, L., Gupta, S., & Gaur, S. (2016). A Focus on Respiratory Tract Infection as an Important Risk Factor in COPD. Insights in Allergy Asthma & Bronchitis, 1(2) (IF-6.957, HI-1).  https://doi.org/10.21767/2471-304X.100008

21.   Saxena, L., & Khanna, M. (2015). Production and Characterization of Human Monoclonal Antibodies from the Cells of A (H1N1)pdm2009 Influenza Virus Infected Indian Donors. Procedia in Vaccinology, 9, 50–58 (IF-0.7, HI-16). https://doi.org/10.1016/j.provac.2015.05.009

22.   Rajput, R., Sharma, G., Rawat, V., Gautam, A., Kumar, B., Pattnaik, B., Pradhan, H. K., & Khanna, M. (2015). Diagnostic Potential of Recombinant scFv Antibodies Generated against Hemagglutinin Protein of Influenza A Virus. Frontiers in Immunology, 6, 440 (IF-8.786, HI-190).  https://doi.org/10.3389/fimmu.2015.00440

23.   Kumar, B., Rajput, R., Pati, D. R., & Khanna, M. (2015). Potent Intracellular Knock-Down of Influenza A Virus M2 Gene Transcript by DNAzymes Considerably Reduces Viral Replication in Host Cells. Molecular Biotechnology, 57(9), 836–845 (IF-2.860, HI-87).  https://doi.org/10.1007/s12033-015-9876-z

24.   Khanna, M., Saxena, L., Rajput, R., Kumar, B., & Prasad, R. (2015). Gene silencing: a therapeutic approach to combat influenza virus infections. Future Microbiology, 10(1), 131–140 (IF-3.553, HI-96).  https://doi.org/10.2217/fmb.14.94

25.   Khanna, M Rajput R. (2014) Influenza virus Induced Cytokine Responses: An Evaluation of Host-Pathogen Association. (2014).  Immunome Research, 01(s2) (IF-9, HI-15).  https://doi:10.4172/1745-7580.s2.00

26.   Khanna, M., Sharma, S., Kumar, B., & Rajput, R. (2014). Protective immunity based on the conserved hemagglutinin stalk domain and its prospects for universal influenza vaccine development. Bio Med Research International, 2014, 546274 (IF-3.411, HI-167). https://doi.org/10.1155/2014/546274

27.   Rajput, R., Khanna, M., & Pradhan, H. K. (2014). Phage-display technology for the production of recombinant monoclonal antibodies. Materials and Methods, 4;873 (IF-3.4, HI-10).  https://doi.org/10.13070/mm.en.4.873

28.   Kumar, B., Kumar, P., Rajput, R., Saxena, L., Daga, M. K., & Khanna, M. (2013). Sequence-specific cleavage of BM2 gene transcript of influenza B virus by 10-23 catalytic motif containing DNA enzymes significantly inhibits viral RNA translation and replication. Nucleic Acid Therapeutics, 23(5), 355–362 (IF-4, HI-73).  https://doi.org/10.1089/nat.2013.0432

29.   Kumar, P., Kumar, B., Rajput, R., Saxena, L., Banerjea, A. C., & Khanna, M. (2013). Cross-protective effect of antisense oligonucleotide developed against the common 3' NCR of influenza A virus genome. Molecular Biotechnology, 55(3), 203–211 (IF-2.860, HI-87).  https://doi.org/10.1007/s12033-013-9670-8

30.   Kumar, P., Gaur, S. N., Pati, D. R., Khanna, M., Kumar, B., Rajput, R., Saxena, L., & LNU, S. (2013). Clinical Presentation of Patients with Seasonal Influenza and Pandemic Influenza A (H1N1-2009) Requiring Hospitalisation. The Indian Journal of Chest Diseases and Allied Sciences, 55(1), 15–19 (IF-0.043, HI-29).  https://doi.org/10.5005/ijcdas-55-1-15

31.   Khanna, M., Saxena, L., Gupta, A., Kumar, B., & Rajput, R. (2013). Influenza pandemics of 1918 and 2009: a comparative account. Future Virology, 8(4), 335–342 (IF-3.015, HI-43).  https://doi.org/10.2217/fvl.13.18 

32.   Rajput, R., Khanna, M., Kumar, P., Kumar, B., Sharma, S., Gupta, N., & Saxena, L. (2012). Small interfering RNA targeting the nonstructural gene 1 transcript inhibits influenza A virus replication in experimental mice. Nucleic Acid Therapeutics, 22(6), 414–422 (IF-4, HI-73).  https://doi.org/10.1089/nat.2012.0359

33.   Kumar, P., Khanna, M., Kumar, B., Rajput, R., & Banerjea, A. C. (2012). A conserved matrix epitope based DNA vaccine protects mice against influenza A virus challenge. Antiviral Research, 93(1), 78–85 (IF-10.103, HI-144).  https://doi.org/10.1016/j.antiviral.2011.10.021

34.   Kumar, B., Khanna, M., Kumar, P., Sood, V., Vyas, R., & Banerjea, A. C. (2012). Nucleic acid-mediated cleavage of M1 gene of influenza A virus is significantly augmented by antisense molecules targeted to hybridize close to the cleavage site. Molecular Biotechnology, 51(1), 27–36 (IF-2.860, HI-87). https://doi.org/10. 1007/s12033-011-9437-z

35.   Kumar B, Kumar B, Rajput R, Daga M K, Singh V and Khanna M. Comparative reproducibiligy of SBYR Green I and TaqMan real-time PCR chemistries for the analysis of matrix and hemagglutinin genes of Influenza A viruses. International Journal of Collaborative Research on Internal Medicine & Public Health. Vol. 4 no. 7 (2012) (IF-4.63, HI-35).

36.    Srivastava, V., Khanna, M., Sharma, S., & Kumar, B. (2012). Resolution of immune response by recombinant transforming growth factor-beta (rTGF-β) during influenza A virus infection. The Indian Journal of Medical Research, 136(4), 641–648 (IF-5.274, HI-96). http://www.ncbi.nlm.nih.gov/ pmc/articles/pmc3516032/  

37.   Kumar, P., Sood, V., Vyas, R., Gupta, N., Banerjea, A. C., & Khanna, M. (2010). Potent inhibition of influenza virus replication with novel siRNA-chimeric-ribozyme constructs. Antiviral Research, 87(2), 204–212 (IF-10.103, HI-144). https://doi.org/10.1016/j.antiviral.2010.05.001

38.   Khanna M, Rajput R, Kumar P, Sharma D, Mathur D, Prasad AK (2011). Potent inhibition of pandemic influenza H1N1 (2009) virus propagation by novel chemically synthesized compounds. Influenza & Respiratory Viruses 5 (Suppl.1), 90-123 (IF-4.4, HI-69).

39.   Kumar, B., Pati, D. R., Khanna, M., Kumar, P., Daga, M. K., Singh, V., Khare, S., & Gaur, S. (2012). Age-Sex Distribution and Seasonality Pattern among Influenza Virus Infected Patients in Delhi, 2009-2010. Indian Journal of Community Medicine : official publication of Indian Association of Preventive & Social Medicine, 37(1), 57–58 (IF-0.9, HI-40). https://doi.org/10.4103/0970-0218.94028

40.   Khanna, M., Kumar, B., Gupta, A., & Kumar, P. (2012). Pandemic Influenza A H1N1 (2009) Virus: Lessons from the Past and Implications for the Future. Virus Disease, 23(1), 12–17 (IF-5.9, HI-66). https://doi.org/10.1007/s13337-012-0066-3

41.   Kumar B, Khanna M, Kumar P, Gupta  A, Daga M.K, Sarkar M.C, Chadha M.S, Mishra A.C, Kaur H (2011). Quantification of viral load in clinical specimens collected from different body sites of patients infected with influenza viruses. International Journal of Medicine and Medical Science 3 (5):144-148 (IF-3.642, HI-74). https://doi.org/10.5897/IJMMS.9000196

42.   Kumar B, Sharma B, Khanna M, Singh V, Daga MK, Vijayan VK, Mishra AC, Chadha MS, Sarkar MC & Kaur H (2010). Comparison of various immunoassay kits for rapid screening of pandemic influenza H1N1-2009 viruses. Journal of Public Health Epidemiology 2:175-179 (IF-2.219).

 http://www.academic journals.org/JPHE/PDF/pdf2010/N...

43.   Kumar, P., Kumar, B., Gupta, A., Sharma, B., Vijayan, V. K., Khare, S., Singh, V., Daga, M. K., Chadha, M. S., Mishra, A. C., Kaur, H., & Khanna, M. (2010). Diagnosis of Novel Pandemic Influenza Virus 2009 H1N1 in Hospitalized Patients. Virus Disease, 21(1), 45–49 (IF-5.9, HI-66).

https://doi.org/10.1007/s13337-010-0005-0

44.   Khanna, M., Ray, A., Rawall, S., Chandna, S., Kumar, B., & Vijayan, V. K. (2010). Detection of influenza virus induced ultrastructural changes and DNA damage. Virus Disease, 21(1), 50–55 (IF-5.9, HI-66). https://doi.org/10.1007/s13337-010-0004-1

45.   Khanna, M., & Gupta, A. (2010). Vaccines for Pandemic Influenza A H1N1 (2009): Where Do We Stand?. Virus Disease, 21(1), 90–91(IF-5.9, HI-66). https://doi.org/10.1007/s13337-010-0013-0

46.   Khanna, M., Kumar, B., Gupta, N., Kumar, P., Gupta, A., Vijayan, V. K., & Kaur, H. (2009). Pandemic swine influenza virus (H1N1): A threatening evolution. Indian Journal of Microbiology, 49(4), 365–369(IF-3.54, HI-58).

 https://doi.org/10.1007/s12088-009-0064-3

47.   Srivastava, V., Rawall, S., Vijayan, V. K., & Khanna, M. (2009). Influenza a virus induced apoptosis: inhibition of DNA laddering & caspase-3 activity by zinc supplementation in cultured HeLa cells. The Indian Journal of Medical Research, 129(5), 579–586 (IF-5.274, HI-96). PMID: 19675388

48.   Khanna, M., Kumar, P., Choudhary, K., Kumar, B., & Vijayan, V. K. (2008). Emerging influenza virus: a global threat. Journal of Biosciences, 33(4), 475–482 (IF-2.795, HI-80). https://doi.org/10.1007/s12038-008-0066-z

49.   Khanna, M., Gupta, N., Gupta, A., & Vijayan, V. K. (2009). Influenza A (H1N1) 2009: a pandemic alarm. Journal of Biosciences, 34(3), 481–489 (IF-2.795, HI-80). https://doi.org/10.1007/s12038-009-0053-z

50.   Nazir, R., Khanna, M., & Kulshrestha, R. (2008). Time course of pulmonary pathology, cytokine influx and their correlation on augmentation of antigen challenge by influenza A virus infection. Indian Journal of Experimental Biology, 46(3), 151–158 (IF-0.6, HI-78).

51.   Kumar P, Srivastava V, Khanna M and Vijayan V K, (2007) Biphasic effect of immune r TGF-β1 on inducible Nitric oxide Synthase during Influenza A virus infection in mice.  Proceedings of Option for Control of Influenza 559-560 (IF-4.4).

52.   Khanna M, Kumar P, Vijayan V K, Singh V. (2007) Release of Macrophage inflammatory protein, IL-6 and Eosinophilic derived neurotoxin into upper respiratory secretions during influenza virus infection in children Indian Journal of Chest Disease and Allied Sciences 49: 249-251 (IF-0.043, HI-29).

53.   Kumar, P., Khanna, M., Srivastava, V., Tyagi, Y. K., Raj, H. G., & Ravi, K. (2005). Effect of quercetin supplementation on lung antioxidants after experimental influenza virus infection. Experimental Lung Research, 31(5), 449–459(IF-2.375, HI-56). https://doi.org/10.1080/019021490927088

54.   Kumar, P., Sharma, S., Khanna, M., & Raj, H. G. (2003). Effect of Quercetin on lipid peroxidation and changes in lung morphology in experimental influenza virus infection. International Journal of Experimental Pathology, 84(3), 127–133 (IF-2.793, HI-79). https://doi.org/10.1046/j.1365-2613.2003.00344.x

55.   Khanna, M., Kumar, P., Chugh, L., Prasad, A. K., & Chhabra, S. K. (2001). Evaluation of influenza virus detection by direct enzyme immunoassay (EIA) and conventional methods in asthmatic patients. The Journal of Communicable Diseases, 33(3), 163–169 (IF-7.590, HI-269).

56.   Khanna, M., Akther, N., Srivastava, V., Kumar, P., & Vijayan, V. K. (2006). Biological and epidemiological aspects of influenza virus H5N1 in context of India. Indian Journal of Experimental Biology, 44(4), 265–278 (IF-0.6, HI-78).             https://pubmed.ncbi.nlm.nih.gov/16629368/

57.   Khanna M, Kumar P. (2002). Influenza: A serious global threat. J. Infect. Dis. Antimicro. Agents. 19; 25-39 (IF-15.441, HI-147).

58.   Khanna M, Srivastava V and Kumar P. (2002). Virological studies in clinical practice: Utility & Indications. Medicine Update Annual Ed. 7/2; 74-78 (IF-16.048).

59.   Khanna M, Kumar P and Prasad AK. Influenza and its role in apoptosis. (2001).Iranian Journal of Allergy, Asthma, and Immunology. 15; 7-12 (IF-1.57, HI-30).

60.   Khanna M, Kumar P, Srivastava LM. (2003) Defective Interlukin-2 and IL-2 receptor expression in pulmonary tuberculosis. Journal of Communicable Diseases. 35 (2) 65-70 (IF-0.27, HI-28).

61.   Sharma S.K., Khilnani,V. Pandey.V.C. and Khanna, M.(1995). Immunological and Pulmonary Function Abnormalties in tropical Pulmonary Eosinophilia. Indian Journal of Medical Research, 101:98-102 (IF-5.274, HI-96). http://icmr.nic.in/ijmr/ijmr.htm

62.   Sharma, S. K., Khanna, M., Sharma, S., Srivastava, L. M., Verma, K., Khilnani, G. C., & Pande, J. N. (1995). Effect of corticosteroid treatment on various serological & bronchoalveolar lavage abnormalities in patients with sarcoidosis. Indian Journal of Medical Research, 101, 207–212 (IF-5.274, HI-96).

63.   Khanna, M., & Srivastava, L. M. (1996). Release of superoxide anion from activated mouse peritoneal macrophages during Mycobacterium tuberculosis infection. Indian Journal of Experimental Biology, 34(5), 468–471 (IF-0.6, HI-78).

64.   Khanna M, Goel A, Jain RC, and Srivastava LM. (1997). Rapid and simple method for detection of rifampicin resistant clinical isolates of M.  Tuberculosis Indian Journal Clinical Biochemistry 12 (suppl); 83-85 (IF-0.38, HI-50).

65.   Khanna M., Chaturvedi U. C., & Mathur A. (1988). Abrogation of helper T cells by dengue virus-induced cytotoxic factor. Current Science, 57(8), 411–414 (IF-1.169, HI-130). http://www.jstor.org/stable/2409015

66.   Khanna M, Chaturvedi UC and Mathur A. (1989). Cytotoxic effects   of dengue virus induced cytotoxin on helper T cell.  Indian Journal of Medical Microbiology 7; 54-57 (IF-1.347, HI-53).

67.   Khanna, M., Chaturvedi, U. C., Srinivasa, B. R., Swaminathan, K. R., & Mathur, A. (1989). Proteinase-like activity in the cytotoxic factor produced by T cells during dengue virus infection. Immunology, 67(1), 32–37 (IF-6.4, HI-81).

68.   Dhawan, R., Khanna, M., Chaturvedi, U. C., & Mathur, A. (1990). Effect of dengue virus-induced cytotoxin on capillary permeability. Journal of Experimental Pathology (Oxford, England), 71(1), 83–88 (IF-2.793, HI-79).

69.   Khanna, M., Chaturvedi, U. C., Sharma, M. C., Pandey, V. C., & Mathur, A. (1990). Increased capillary permeability mediated by a dengue virus-induced lymphokine. Immunology, 69(3), 449–453 (IF-6.4, HI-81).

70.   Dhawan R, Khanna M, Chaturvedi UC and Mathur A. (1990) Role of calcium in induction and secretion dengue virus-induced cytokines. Journal of Bio Sciences 15; 409-416 (IF-10.750, HI-36).

71.   Dhawan, R., Chaturvedi, U. C., Khanna, M., Mathur, A., Tekwani, B. L., Pandey, V. C., & Rai, R. N. (1991). Obligatory role of Ca2+ in the cytotoxic activity of dengue virus-induced cytotoxin. International Journal of Experimental Pathology, 72(1), 31–39 (IF-2.793, HI-79).

72.   Khanna, M., Chaturvedi, U. C., Dhawan, R., Tekwani, B. L., & Pandey, V. C. (1991). Presence of Ca2+ is obligatory for the cytotoxic activity of dengue virus-induced cytotoxic factor. Immunology, 72(1), 73–78 (IF-6.4, HI-81).

73.   Chaturvedi, U. C., Dhawan, R., Khanna, M., & Mathur, A. (1991). Breakdown of the blood-brain barrier during dengue virus infection of mice. The Journal of General Virology, 72 ( Pt 4), 859–866 (IF-5.141, HI-181).  https://doi.org/10.1099/0022-1317-72-4-859

74.   Khanna, M., & Chaturvedi, U. C. (1992). Purification and amino-terminal sequence of the dengue virus-induced cytotoxic factor. International Journal of Experimental Pathology, 73(1), 43–49 (IF-2.793, HI-79).

 Book Chapters

1.       Nishtha Agrawal, Indu Singh, Madhu Khanna, Gagan Dhawan, Pradeep Kumar and Uma Dhawan. Understanding the Pharmacology and Pharmacotherapeutics for Infectious Diseases. 53-81 (2022) doi.org/10.1007/978-981-16-9190-4_3

2.       Khanna M, Saxena L, Rajput R, Sharma S, Kumar B. Biotechnology in development of viral markers.532-550.In: Biotechnology in Medicine and Herbal Drug Development, Gill SS, Singh Z, Bansal P, eds.  Basera Verlag, Germany. (2014) ISBN: 978-81-92064-0-4.

3.      Khanna M, Saxena L. RNA interference and its applications in human health.161-170.In: Recent Advances in Assisted Reproductive Technology. Gill SS, Singh Z, Bansal P, eds. Gulab Publishers, Sangur, India. (2013) ISBN: 978-81-92064-0-6.

4.       Khanna M, Saxena L. RNA interference and its applications in human health.161-170.In: Recent Advances in Assisted Reproductive Technology. Gill SS, Singh Z, Bansal P, eds. Gulab Publishers, Sangur, India. (2013) ISBN: 978-81-92064-0-6.

5.       Khanna M, Srivastava V., Structure and Classification of Influenza Virus. P 11 – 23. In: Tripathi M. Mathew & Thankam Mathew, eds. Influenza and Its’ Global Public Health Significance Thajema Publishers 31 Glen view Dr. West Orange NJ 07052 USA: (2006).

6.      Khanna M, Srivastava V., Clinical and Laboratory Diagnosis of Influenza Virus. P 138 – 151. In: Tripathi M. Mathew & Thankam Mathew, eds. Influenza and Its’ Global Public Health Significance Thajema Publishers 31 Glen view Dr. West Orange NJ 07052 USA: (2006).

7.      Khanna M, Nazir R, Srivastava V., Prophylaxis Prevention and Treatment for Influenza A,B,C. p 169 – 191. In: Tripathi M. Mathew & Thankam Mathew, eds. Influenza and Its’ Global Public Health Significance Thajema Publishers 31 Glen view Dr. West Orange NJ 07052 USA: (2006).

8.      Khanna M, Srivastava V., Influenza Pandemic Preparedness. P 192 – 201. In: Tripathi M. Mathew & Thankam Mathew, eds. Influenza and Its’ Global Public Health Significance Thajema Publishers 31 Glen view Dr. West Orange NJ 07052 USA: (2006).

 

 

                                                                                     (Prof.Madhu Khanna)

                                                                        Director Professor

                                                            Department of Microbiology (Virology Unit)

Vallabhbhai Patel Chest Institute

University of Delhi

 

Delhi-110007